Rlf^MommeD8
Chemically induced Allele Detail

Summary

• Symbol: Rlf^MommeD8
• Name: rearranged L-myc fusion sequence; modifier of murine metastable epialleles, D8
• MGI ID: MGI:3821599
• Gene: Rlf Location: Chr4:121003080-121072318 bp, - strand Genetic Position: Chr4, 56.8 cM
• Alliance: Rlf^MommeD8 page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: A G-to-T single point mutation in exon 8 is predicted to result in a C155F amino acid substitution in the encoded protein. Reduced amounts of encoded protein were detected on Western blot of embryonic tissue, suggesting that this allele is hypomorphic. (J:201508)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rlf Mutation: 82 strains or lines available

References

• Original: J:142335 Ashe A, et al., A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development. Genome Biol. 2008 Dec 19;9(12):R182
• All: 2 reference(s)