Pak6^tm1Amin
Targeted Allele Detail

Summary

• Symbol: Pak6^tm1Amin
• Name: p21 (RAC1) activated kinase 6; targeted mutation 1, Audrey Minden
• MGI ID: MGI:3821622
• Gene: Pak6 Location: Chr2:118493784-118528501 bp, + strand Genetic Position: Chr2, 59.41 cM
• Alliance: Pak6^tm1Amin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141962
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All of exon 1 and part of exon 2 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:141962)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pak6 Mutation: 27 strains or lines available

References

• Original: J:141962 Nekrasova T, et al., Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion. Dev Biol. 2008 Oct 1;322(1):95-108
• All: 2 reference(s)