Crybb2^tm1Itl
Targeted Allele Detail

Summary

• Symbol: Crybb2^tm1Itl
• Name: crystallin, beta B2; targeted mutation 1, inGenious Targeting Laboratory
• MGI ID: MGI:3821715
• Synonyms: Crybb2^-, Crybb2^tm1Igl
• Gene: Crybb2 Location: Chr5:113206124-113217983 bp, - strand Genetic Position: Chr5, 55.38 cM
• Alliance: Crybb2^tm1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142278
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on lens extracts. (J:142278, J:333315)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crybb2 Mutation: 13 strains or lines available

References

• Original: J:333315 Zhang J, et al., Establishment of a betaB2crystallin gene knockout mice model. Acad J Sec Mil Med Univ. 2006;27:1246-1248
• All: 5 reference(s)