Myh11^tm2Peri
Targeted Allele Detail

Summary

• Symbol: Myh11^tm2Peri
• Name: myosin, heavy polypeptide 11, smooth muscle; targeted mutation 2, Muthu Periasamy
• MGI ID: MGI:3821724
• Synonyms: SM2^-
• Gene: Myh11 Location: Chr16:14012392-14109227 bp, - strand Genetic Position: Chr16, 9.71 cM
• Alliance: Myh11^tm2Peri page

Myh11^tm2Peri/Myh11^tm2Peri mice exhibit segmental distention of alimentary tract, retention of urine in renal pelvis/bladder and development of end-stage hydronephrosis

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142230
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 41 was replaced with a neo cassette. The absence of isoform SM2 and reduced presence of isoform SM1 was confirmed by western blot analysis on bladder extracts. (J:142230)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myh11 Mutation: 94 strains or lines available

References

• Original: J:142230 Chi M, et al., Ablation of smooth muscle myosin heavy chain SM2 increases smooth muscle contraction and results in postnatal death in mice. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18614-8
• All: 1 reference(s)