Arfrp1^tm2Asch
Targeted Allele Detail

Summary

• Symbol: Arfrp1^tm2Asch
• Name: ADP-ribosylation factor related protein 1; targeted mutation 2, Annette Schurmann
• MGI ID: MGI:3821725
• Gene: Arfrp1 Location: Chr2:180999483-181007197 bp, - strand Genetic Position: Chr2, 103.63 cM
• Alliance: Arfrp1^tm2Asch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142321
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 1 and a floxed PGK-neo cassette was inserted in intron 4. The neomycin selection cassette was subsequently excised from correctly targeted ES cells by transient cre expression. (J:142321)

Expression

In Mice Carrying this Mutation:

34 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arfrp1 Mutation: 19 strains or lines available

References

• Original: J:142321 Zahn C, et al., ADP-ribosylation factor-like GTPase ARFRP1 is required for trans-Golgi to plasma membrane trafficking of E-cadherin. J Biol Chem. 2008 Oct 3;283(40):27179-88
• All: 8 reference(s)