Dlgap5^tm1Tfts
Targeted Allele Detail

Summary

• Symbol: Dlgap5^tm1Tfts
• Name: DLG associated protein 5; targeted mutation 1, Ting-Fen Tsai
• MGI ID: MGI:3821727
• Synonyms: Hurp^-
• Gene: Dlgap5 Location: Chr14:47625238-47655657 bp, - strand Genetic Position: Chr14, 24.6 cM
• Alliance: Dlgap5^tm1Tfts page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142315
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neo cassette followed by a 4.47 kb genomic DNA fragment containing parts of exons 2 and 4 and all of exon 3 was inserted. Northern blot analysis confirmed the absence of mRNA expression in homozygous mice. (J:142315)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dlgap5 Mutation: 39 strains or lines available

References

• Original: J:142315 Tsai CY, et al., Hurp deficiency in mice leads to female infertility caused by an implantation defect. J Biol Chem. 2008 Sep 26;283(39):26302-6
• All: 2 reference(s)