Ffar1^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Ffar1^tm1Dgen
• Name: free fatty acid receptor 1; targeted mutation 1, Deltagen
• MGI ID: MGI:3821733
• Synonyms: GPR40 KO
• Gene: Ffar1 Location: Chr7:30559993-30560895 bp, - strand Genetic Position: Chr7, 19.25 cM
• Alliance: Ffar1^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141957
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 152 bp fragment corresponding to positions 143-294 of the open reading frame was replaced with a neomycin selection cassette. RT-PCR confirmed that mRNA was not produced. (J:141957)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ffar1 Mutation: 18 strains or lines available

References

• Original: J:141957 Lan H, et al., Lack of FFAR1/GPR40 does not protect mice from high-fat diet-induced metabolic disease. Diabetes. 2008 Nov;57(11):2999-3006
• All: 6 reference(s)