Igf1^tm2Arge
Targeted Allele Detail

Summary

• Symbol: Igf1^tm2Arge
• Name: insulin-like growth factor 1; targeted mutation 2, Argiris Efstratiadis
• MGI ID: MGI:3821754
• Synonyms: Igf1^flox
• Gene: Igf1 Location: Chr10:87694127-87772904 bp, + strand Genetic Position: Chr10, 43.7 cM
• Alliance: Igf1^tm2Arge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142247
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Using ES cells containing Igf1^tm1Arge in which exon 4 was replaced with a neo cassette, exon three was replaced with a full-length cDNA of the gene preceded by a floxed puromycin resistance cassette and three polyadenylation sequences from SV40. The full-length cDNA is only expressed when the polyadenylation sites have been removed. (J:142247)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igf1 Mutation: 29 strains or lines available

References

• Original: J:142247 Stratikopoulos E, et al., The hormonal action of IGF1 in postnatal mouse growth. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19378-83
• All: 1 reference(s)