Pcdhg^tm2Xzw
Targeted Allele Detail

Summary

• Symbol: Pcdhg^tm2Xzw
• Name: protocadherin gamma cluster; targeted mutation 2, Xiaozhong Wang
• MGI ID: MGI:3821773
• Synonyms: Pcdh-gamma^fcon3, Pcdhg^fcon3, Pcdhg^tm2Jrs
• Gene: Pcdhg Location: unknown Genetic Position: Chr18, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142186
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The Pcdh-gamma targeting vector was designed to insert a loxP site upstream of constant exon 3 of gamma-protocadherin (Pcdh-gamma) which was fused to EGFP, followed by a loxP-flanked PGK-neomycin resistance (neo) cassette. (J:142186)

Expression

In Mice Carrying this Mutation:	37 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pcdhg Mutation: 13 strains or lines available

References

• Original: J:142186 Lefebvre JL, et al., {gamma}-Protocadherins regulate neuronal survival but are dispensable for circuit formation in retina. Development. 2008 Dec;135(24):4141-51
• All: 23 reference(s)