Ncor1^tm1Anh
Targeted Allele Detail

Summary

• Symbol: Ncor1^tm1Anh
• Name: nuclear receptor co-repressor 1; targeted mutation 1, Anthony N Hollenberg
• MGI ID: MGI:3821874
• Synonyms: NCoR^lox
• Gene: Ncor1 Location: Chr11:62207132-62348200 bp, - strand Genetic Position: Chr11, 38.08 cM, cytoband B2
• Alliance: Ncor1^tm1Anh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142045
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 38 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 41. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exons 38 through 41 floxed. These exons encode two of the three receptor interacting domains (N2 and N3). (J:142045)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ncor1 Mutation: 396 strains or lines available

References

• Original: J:142045 Astapova I, et al., The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19544-9
• All: 14 reference(s)