Flrt3^tm1Kln
Targeted Allele Detail

Summary

• Symbol: Flrt3^tm1Kln
• Name: fibronectin leucine rich transmembrane protein 3; targeted mutation 1, Rudiger Klein
• MGI ID: MGI:3821876
• Synonyms: FLRT3^lacZ
• Gene: Flrt3 Location: Chr2:140500118-140513396 bp, - strand Genetic Position: Chr2, 69.2 cM
• Alliance: Flrt3^tm1Kln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142039
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region contained within exon 3 was replaced with a lacZ gene and floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on E8.5 to E9.5 whole embryo extracts. (J:142039)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Flrt3 Mutation: 44 strains or lines available

References

• Original: J:142039 Egea J, et al., Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation. Genes Dev. 2008 Dec 1;22(23):3349-3362
• All: 7 reference(s)