Flrt3^tm2Kln
Targeted Allele Detail

Summary

• Symbol: Flrt3^tm2Kln
• Name: fibronectin leucine rich transmembrane protein 3; targeted mutation 2, Rudiger Klein
• MGI ID: MGI:3821877
• Gene: Flrt3 Location: Chr2:140500118-140513396 bp, - strand Genetic Position: Chr2, 69.2 cM
• Alliance: Flrt3^tm2Kln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142039
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region contained within exon 3 was replaced with a floxed neo cassette. Germ line, cre mediated recombination was used to remove the neo cassette. The absence of protein expression was confirmed by western blot analysis on E8.5 to E9.5 whole embryo extracts. (J:142039)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Flrt3 Mutation: 44 strains or lines available

References

• Original: J:142039 Egea J, et al., Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation. Genes Dev. 2008 Dec 1;22(23):3349-3362
• All: 3 reference(s)