Snap25^tm1.1Bark
Targeted Allele Detail

Summary

• Symbol: Snap25^tm1.1Bark
• Name: synaptosomal-associated protein 25; targeted mutation 1.1, Christina Bark
• MGI ID: MGI:3821974
• Gene: Snap25 Location: Chr2:136555373-136624348 bp, + strand Genetic Position: Chr2, 67.56 cM
• Alliance: Snap25^tm1.1Bark page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142096
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5b was replaced with the sequence for an additional exon5a. A floxed cre cassette used for selection purposes was inserted into intron 5 and removed by germ line, cre mediated recombination. The lack of B isoform mRNA was confirmed by semi-quantitative PCR while the overall protein expression level from this gene was slightly increased as determined by protein quantitation. (J:142096)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Snap25 Mutation: 26 strains or lines available

References

• Original: J:142096 Johansson JU, et al., An ancient duplication of exon 5 in the Snap25 gene is required for complex neuronal development/function. PLoS Genet. 2008 Nov;4(11):e1000278
• All: 6 reference(s)