Bmp2^tm1Mis
Targeted Allele Detail

Summary

• Symbol: Bmp2^tm1Mis
• Name: bone morphogenetic protein 2; targeted mutation 1, Yuji Mishina
• MGI ID: MGI:3822026
• Synonyms: fn
• Gene: Bmp2 Location: Chr2:133394079-133404805 bp, + strand Genetic Position: Chr2, 65.21 cM
• Alliance: Bmp2^tm1Mis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141834
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an frt flanked neo cassette, second loxP site, and a human alkaline phosphatase gene were inserted in the 3' UTR of exon 3. Quantitative RT-PCR indicated a decrease in RNA expression in homozygous embryos. (J:141834)

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bmp2 Mutation: 27 strains or lines available

References

• Original: J:141834 Singh AP, et al., Influences of reduced expression of maternal bone morphogenetic protein 2 on mouse embryonic development. Sex Dev. 2008;2(3):134-41
• All: 2 reference(s)