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Tg(CAG-cat,-Map2k1*)243Rbns
Transgene Detail
Summary
Symbol: Tg(CAG-cat,-Map2k1*)243Rbns
Name: transgene insertion 243, Jeffrey Robbins
MGI ID: MGI:3822131
Synonyms: CAGCAT-caMEK1
Transgene: Tg(CAG-cat,-Map2k1*)243Rbns  Location: unknown  
Alliance: Tg(CAG-cat,-Map2k1*)243Rbns page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Conditional ready, Constitutively active, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe ubiquitous CAG (chicken beta actin) promoter was used to drive cre-dependent expression of a constitutively active Map2k1 gene, in which glutamines where substituted for serines at positions 217 and 221, following removal of an intervening floxed chloramphenicol (cat) gene. Several lines were created with similar expression patterns. (No line names given) (J:142212)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:142212 Krenz M, et al., Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18930-5
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory