Tg(CAG-cat,-Map2k1*)243Rbns
Transgene Detail

Summary

• Symbol: Tg(CAG-cat,-Map2k1*)243Rbns
• Name: transgene insertion 243, Jeffrey Robbins
• MGI ID: MGI:3822131
• Synonyms: CAGCAT-caMEK1
• Transgene: Tg(CAG-cat,-Map2k1*)243Rbns Location: unknown
• Alliance: Tg(CAG-cat,-Map2k1*)243Rbns page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Conditional ready, Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The ubiquitous CAG (chicken beta actin) promoter was used to drive cre-dependent expression of a constitutively active Map2k1 gene, in which glutamines where substituted for serines at positions 217 and 221, following removal of an intervening floxed chloramphenicol (cat) gene. Several lines were created with similar expression patterns. (No line names given) (J:142212)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:142212 Krenz M, et al., Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18930-5
• All: 6 reference(s)