Tg(Myh6-Ptpn11*Q79R)197Rbns
Transgene Detail

Summary

• Symbol: Tg(Myh6-Ptpn11*Q79R)197Rbns
• Name: transgene insertion 197, Jeffrey Robbins
• MGI ID: MGI:3822133
• Synonyms: alpha-MHC-Q97R197
• Transgene: Tg(Myh6-Ptpn11*Q79R)197Rbns Location: unknown
• Alliance: Tg(Myh6-Ptpn11*Q79R)197Rbns page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Ptpn11*Q79R)197Rbns expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ptpn11 (MGI:99511)	Transgene codes for a protein with a glutamin to arginine mutation.

• Mutation details: The promoter was used to drive expression of Ptpn11 containing the amino acid substitution of arginine for glutamine at position 79 in the postnatal heart. This mutation results in an increase in phosphatase activity. Several lines were created and line 197 was used in subsequent experiments. (J:123963)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:123963 Nakamura T, et al., Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome. J Clin Invest. 2007 Aug;117(8):2123-32
• All: 1 reference(s)