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Mir133a-1tm1.1Eno
Targeted Allele Detail
Summary
Symbol: Mir133a-1tm1.1Eno
Name: microRNA 133a-1; targeted mutation 1.1, Eric N Olson
MGI ID: MGI:3822154
Synonyms: Mirn133a-1ko
Gene: Mir133a-1  Location: Chr18:10782909-10782976 bp, - strand  Genetic Position: Chr18, 5.4 cM
Alliance: Mir133a-1tm1.1Eno page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:142220
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe 68 bp pre-miR stem loop found in intron 23 of Mib1 was replaced by an FRT flanked neomycin resistance cassette. Mib1 expression is not affected. Mice derived from correctly targeted ES cells were crossed to Tg(ACTFLPe)9205Dym mice to excise the neomycin selection cassette. (J:142220)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mir133a-1 Mutation:  2 strains or lines available
References
Original:  J:142220 Liu N, et al., microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev. 2008 Dec 1;22(23):3242-54
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory