Mir133a-2^tm1.1Eno
Targeted Allele Detail

Summary

• Symbol: Mir133a-2^tm1.1Eno
• Name: microRNA 133a-2; targeted mutation 1.1, Eric N Olson
• MGI ID: MGI:3822158
• Synonyms: Mirn133a-2^ko
• Gene: Mir133a-2 Location: Chr2:180040172-180040275 bp, + strand Genetic Position: Chr2, 102.93 cM
• Alliance: Mir133a-2^tm1.1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142220
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 108 bp pre-miR stem loop was replaced by an FRT flanked neomycin resistance cassette. Mice derived from correctly targeted ES cells were crossed to Tg(ACTFLPe)9205Dym mice to excise the neomycin selection cassette. (J:142220)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir133a-2 Mutation: 1 strain or line available

References

• Original: J:142220 Liu N, et al., microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev. 2008 Dec 1;22(23):3242-54
• All: 5 reference(s)