Ifnar1^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ifnar1^m1Btlr
• Name: interferon (alpha and beta) receptor 1; mutation 1, Bruce Beutler
• MGI ID: MGI:3822164
• Synonyms: macro-1
• Gene: Ifnar1 Location: Chr16:91282126-91304329 bp, + strand Genetic Position: Chr16, 52.98 cM
• Alliance: Ifnar1^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutant phenotype was discovered in a screen of macrophages from G3 progeny of an ENU mutagenized male mouse for their ability to control viral infection. The mutation has been identified as an A to C transversion at nucleotide position 1150 (Genbank: NM_010508), in the eighth of the gene's 11 exons. It results in replacement of threonine by proline at amino acid position 341 of the protein (T341P), in its extracellular domain. (J:142790)
• Inheritance: Recessive

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Ifnar1^m1Btlr/Ifnar1^m1Btlr	C57BL/6J-Ifnar1^m1Btlr

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
hematopoietic system	√
abnormal macrophage physiology	√
immune system	√
immune system phenotype	N
abnormal macrophage physiology	√
decreased interferon-alpha secretion	√
decreased interferon-beta secretion	√
increased susceptibility to Adenoviridae infection	√
increased susceptibility to Herpesvirales infection	√
increased susceptibility to Riboviria infection	√
increased susceptibility to Orthomyxoviridae infection	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ifnar1 Mutation: 60 strains or lines available

References

• Original: J:142790 Won S, et al., Record for "macro-1" updated December 18, 2008. MGI Direct Data Submission. 2008
• All: 3 reference(s)