Spint1^tm1Bug
Targeted Allele Detail

Summary

• Symbol: Spint1^tm1Bug
• Name: serine protease inhibitor, Kunitz type 1; targeted mutation 1, Thomas H Bugge
• MGI ID: MGI:3822295
• Synonyms: Spint1^-
• Gene: Spint1 Location: Chr2:119067841-119079995 bp, + strand Genetic Position: Chr2, 59.97 cM, cytoband E5
• Alliance: Spint1^tm1Bug page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142708
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding exons are replaced by a neomycin selection cassette. Absence of mRNA was confirmed by Northern blot analysis. (J:142708)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spint1 Mutation: 26 strains or lines available

References

• Original: J:142708 Szabo R, et al., Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development. Oncogene. 2007 Mar 8;26(11):1546-56
• All: 7 reference(s)