Tg(Cyp21a1-Apoe)619Fet
Transgene Detail

Summary

• Symbol: Tg(Cyp21a1-Apoe)619Fet
• Name: transgene insertion 619, Fayanne Thorngate
• MGI ID: MGI:3822316
• Synonyms: Line 619
• Transgene: Tg(Cyp21a1-Apoe)619Fet Location: unknown
• Alliance: Tg(Cyp21a1-Apoe)619Fet page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Cyp21a1-Apoe)619Fet expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Apoe (MGI:88057)

• Mutation details: A construct containing approximately 6 kb of the mouse Cyp21a1 promoter attached to the mouse Apoe gene was used for injection into fertilized FVB/N oocytes. Ten independent founder lines were generated. Line 619 was donated to the Jackson Laboratory and is representative of low expressing Apoe lines (lines 619 and 620). Only adrenal expression of Apoe was detected for these lines with Line 619 having the lowest mRNA expression (1.6 pg Apoe mRNA per microgram of total RNA). Mice have only 1-2% of wild-type plasma Apoe protein level. (J:130658)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:130658 Thorngate FE, et al., Low levels of extrahepatic nonmacrophage ApoE inhibit atherosclerosis without correcting hypercholesterolemia in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 2000 Aug;20(8):1939-45
• All: 3 reference(s)