Tg(Cyp21a1-Apoe)614Fet
Transgene Detail

Summary

• Symbol: Tg(Cyp21a1-Apoe)614Fet
• Name: transgene insertion 614, Fayanne Thorngate
• MGI ID: MGI:3822327
• Synonyms: Line 614
• Transgene: Tg(Cyp21a1-Apoe)614Fet Location: unknown
• Alliance: Tg(Cyp21a1-Apoe)614Fet page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Cyp21a1-Apoe)614Fet expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Apoe (MGI:88057)

• Mutation details: A construct containing approximately 6 kb of the mouse Cyp21a1 promoter attached to the mouse Apoe gene was used for injection into fertilized FVB/N oocytes. Ten independent founder lines were generated. Line 614 is representative of high expressing Apoe lines (lines 614, 615, and 616). (J:130658)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:130658 Thorngate FE, et al., Low levels of extrahepatic nonmacrophage ApoE inhibit atherosclerosis without correcting hypercholesterolemia in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 2000 Aug;20(8):1939-45
• All: 1 reference(s)