Epha1^tm1Sld
Targeted Allele Detail

Summary

• Symbol: Epha1^tm1Sld
• Name: Eph receptor A1; targeted mutation 1, Shannon L Duffy
• MGI ID: MGI:3822370
• Gene: Epha1 Location: Chr6:42335421-42350202 bp, - strand Genetic Position: Chr6, 20.65 cM
• Alliance: Epha1^tm1Sld page

Uterovaginal abnormalities in Epha1^tm1Sld/Epha1^tm1Sld mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142722
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing an IRES-ALPP reporter gene and floxed neo gene was inserted into exon 2. Germ line, cre mediated recombination was used to remove the neo cassette. The absence of transcript expression was confirmed by QPCR of liver extracts. (J:142722)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Epha1 Mutation: 51 strains or lines available

References

• Original: J:142722 Duffy SL, et al., Generation and characterization of EphA1 receptor tyrosine kinase reporter knockout mice. Genesis. 2008 Oct;46(10):553-61
• All: 3 reference(s)