Epb41l5^tm1Sia
Targeted Allele Detail

Summary

• Symbol: Epb41l5^tm1Sia
• Name: erythrocyte membrane protein band 4.1 like 5; targeted mutation 1, Shinichi Aizawa
• MGI ID: MGI:3822451
• Gene: Epb41l5 Location: Chr1:119472767-119576730 bp, - strand Genetic Position: Chr1, 52.32 cM
• Alliance: Epb41l5^tm1Sia page

Epb41l5^tm1Sia/Epb41l5^tm1Sia mice display mesodermal and epithelial-mesenchymal transition defects

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142596
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed construct containing lacZ and an FRT flanked neomycin selection cassette was inserted at the second ATG in the first coding exon. Expression of the lacZ reporter is very low. RT-PCR indicated the absence of mRNA and Western blot analysis indicated that no protein is produced. (J:142596)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epb41l5 Mutation: 46 strains or lines available

References

• Original: J:142596 Hirano M, et al., EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. J Cell Biol. 2008 Sep 22;182(6):1217-30
• All: 1 reference(s)