Hesx1^tm1(cre)Jpmb
Targeted Allele Detail

Summary

• Symbol: Hesx1^tm1(cre)Jpmb
• Name: homeobox gene expressed in ES cells; targeted mutation 1, Juan Pedro Martinez Barbera
• MGI ID: MGI:3822473
• Synonyms: Hesx1^Cre
• Gene: Hesx1 Location: Chr14:26716373-26724286 bp, + strand Genetic Position: Chr14, 16.09 cM, cytoband A3-B
• Alliance: Hesx1^tm1(cre)Jpmb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135132
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Hesx1^tm1(cre)Jpmb expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hesx1 (MGI:96071)

• Mutation details: The coding region of the Hesx1 gene was replaced with sequence encoding Cre recombinase, a polyA sequence and an Frt-flanked PGK-Neo cassette, via homologous recombination. The targeting vector was electroporated into CCE ES cells. ES cells were injected into B6 blastocysts to generate mice. Subsequently, the Pgk-Neo cassette was excised by crossing mice to ACTB:FLPe transgenic animals and maintained on a C57BL/6J background. (J:135132)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hesx1 (mouse) Summary of all recombinase alleles driven by Hesx1. Alliance mouse Hesx1 gene page

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Hesx1^tm1(cre)Jpmb

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hesx1 Mutation: 14 strains or lines available

References

• Original: J:135132 Andoniadou CL, et al., Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain. Development. 2007 Apr;134(8):1499-508
• All: 16 reference(s)