Sirt3^tm1.1Cxd
Targeted Allele Detail

Summary

• Symbol: Sirt3^tm1.1Cxd
• Name: sirtuin 3; targeted mutation 1.1, Chu-Xia Deng
• MGI ID: MGI:3822536
• Synonyms: SIRT3^deltaE2-E4
• Gene: Sirt3 Location: Chr7:140443579-140462222 bp, - strand Genetic Position: Chr7, 86.07 cM, cytoband F4
• Alliance: Sirt3^tm1.1Cxd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142586
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 4 were removed by germ line, cre mediated recombination. The absence of protein expression was confirmed by western blot analysis on kidney, liver and heart extracts. (J:142586)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sirt3 Mutation: 32 strains or lines available

References

• Original: J:142586 Ahn BH, et al., A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14447-52
• All: 9 reference(s)