Rims1^tm3Sud
Targeted Allele Detail

Summary

• Symbol: Rims1^tm3Sud
• Name: regulating synaptic membrane exocytosis 1; targeted mutation 3, Thomas C Sudhof
• MGI ID: MGI:3822548
• Synonyms: fRIM1, RIM1alphabeta^floxed
• Gene: Rims1 Location: Chr1:22356475-22845203 bp, - strand Genetic Position: Chr1, 8.54 cM, cytoband A5
• Alliance: Rims1^tm3Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143053
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 6 and an frt-flanked double neo cassette with a 5' loxP site was inserted downstream of exon 6. The neo cassette was removed by germ line, flp mediated recombination leaving exon 6 floxed. (J:143053)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rims1 Mutation: 88 strains or lines available

References

• Original: J:143053 Kaeser PS, et al., RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions. J Neurosci. 2008 Dec 10;28(50):13435-47
• All: 35 reference(s)