H2-T3^tm1Luc
Targeted Allele Detail

Summary

• Symbol: H2-T3^tm1Luc
• Name: histocompatibility 2, T region locus 3; targeted mutation 1, Luc Van Kaer
• MGI ID: MGI:3822740
• Synonyms: TL^-
• Gene: H2-T3 Location: Chr17:36496463-36501043 bp, - strand Genetic Position: Chr17, 18.99 cM
• Alliance: H2-T3^tm1Luc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142515
• Parent Cell Line: BL/6-III (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Depending on the background strain, thymic leukemia antigen (TL) can be encoded by one to three genes. This locus contains the sole gene encoding TL antigen in C57BL/6 mice. Exon 3 of the gene was disrupted by the insertion of a neomycin resistance cassette. Gene inactivation was confirmed in homozygote C57BL/6 mice by a lack of TL antigen detected by flow cytometry on intestinal epithelium. (J:142515)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any H2-T3 Mutation: 25 strains or lines available

References

• Original: J:142515 Olivares-Villagomez D, et al., Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17931-6
• All: 3 reference(s)