Guca1b^tm1Amd
Targeted Allele Detail

Summary

• Symbol: Guca1b^tm1Amd
• Name: guanylate cyclase activator 1B; targeted mutation 1, Alexander M Dizhoor
• MGI ID: MGI:3822772
• Gene: Guca1b Location: Chr17:47696318-47703892 bp, + strand Genetic Position: Chr17, 23.04 cM
• Alliance: Guca1b^tm1Amd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142552
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 and 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on retinal extracts. (J:142552)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Guca1b Mutation: 9 strains or lines available

References

• Original: J:142552 Makino CL, et al., A role for GCAP2 in regulating the photoresponse. Guanylyl cyclase activation and rod electrophysiology in GUCA1B knock-out mice. J Biol Chem. 2008 Oct 24;283(43):29135-43
• All: 4 reference(s)