Tg(B4galt1-Aurkb*K111R*L323I)1Saco
Transgene Detail

Summary

• Symbol: Tg(B4galt1-Aurkb*K111R*L323I)1Saco
• Name: transgene insertion 1, Paolo Sassone-Corsi
• MGI ID: MGI:3822833
• Transgene: Tg(B4galt1-Aurkb*K111R*L323I)1Saco Location: unknown
• Alliance: Tg(B4galt1-Aurkb*K111R*L323I)1Saco page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(B4galt1-Aurkb*K111R*L323I)1Saco expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Aurkb (MGI:107168)	Transgene codes for a protein with lysine to arginine and leucine to isoleucine mutations.

• Mutation details: A Myc-tagged Aurkb cDNA containing mutations causing a lysine to arginine substitution at codon 111 and a leucine to isoleucine substitution at codon 323 was placed under the control of the B4galt1 promoter which becomes active in meiotic cells after 21 days of age. (J:142947)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:142947 Kimmins S, et al., Differential functions of the Aurora-B and Aurora-C kinases in mammalian spermatogenesis. Mol Endocrinol. 2007 Mar;21(3):726-39
• All: 1 reference(s)