Summary |
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Variant origin |
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Variant description |
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:142667Chromosome substitution strains derived from A/J donor chromosomes on a C57BL/6J genetic background were used to map QTL associated with 90 phenotypes including blood, bone and metabolic traits. Intercrosses between (C57BL/6J-Chr 6A/J/NaJ x C57BL/6J)F2and (C57BL/6J-Chr 10A/J/NaJ x C57BL/6J)F2 mapped several obesity and liver triglyceride QTL on chromosomes 6 and 10. Animals were placed on a high fat diet at 5 weeks of age and weighed every 2 weeks for 100 days. Background strain C57BL/6J displays increased body weight and liver triglyceride levels compared to donor strain A/J. Two traits were explored in congenic strains containing nested series of segments derived from chromsomes 6 and 10; CSS-6 and -10 for diet-induced obesity and CSS-10 for levels of liver triglycerides.Obrq1 (obesity resistance QTL 1), Obrq2, Obrq3 and Obrq4 mapped to mouse Chromosome 6. The order of the QTL is centromere - Obrq2 - Obrq3 - Obrq4 - Obrq1 - telomere. Obrq2 was mapped in 6C2 (B6.A-(D6Mit138-D6Mit159)/6C2Na) and was linked with D6Mit159 within the congenic interval.Obrq3 was mapped in 6C3 (B6.A-(D6Mit138-D6Mit223)/6C3Na) and was linked with D6Mit223 within the congenic interval. Obrq4 was mapped in 6C4 (B6.A-(D6Mit138-D6Mit274)/6C4/Na and was linked D6Mit274 within the congenic interval.Obrq1 was mapped in 6C12 (B6.A-(D6Mit284-D6Mit15)/6C12Na) and was flanked within the congenic interval by D6Mit284 and D6Mit287 within the interval. [Fig.3, SI]QTL identified on the Chromosome 10:Obrq9 (obesity resistance QTL 9) was mapped in 10C1 (B6.A-rs29331213/10C1Na) linked with rs29331213 within the interval.Obrq10 was mapped in 10C2 (B6.A-(rs13480792-rs29331213)/10C2Na) and is linked with rs13480792 within the congenic interval.Obrq11 was mapped in 10C6 (B6.A-(D10Mit230-rs29331213)/10C6Na) flanked by markers D10Mit230 and D10Mit95 within the congenic interval. Obrq12 was mapped in 10C7 (B6.A-(rs13480651-rs29331213)/10C7Na) flanked by markers rs13480651 and D10Mit42 within the congenic interval.Ltgq1 was mapped in 10C9 (B6.A-(rs29359333-rs29375724)/10C9Na) linked with rs29359333.Ltgq2 (liver triglyceride QTL 1) was mapped in 10C1 (B6.A-rs29331213/10C1Na)and was also linked with rs29331213. The order of liver triglyceride and and obesity QTL is centromere - Ltgq1 -Obrq12 - Obrq11 - Obrq10 - Obrq9/Ltgq2 - telomere. [ Fig S2 and SI]. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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