Slc26a9^tm1Sole
Targeted Allele Detail

Summary

• Symbol: Slc26a9^tm1Sole
• Name: solute carrier family 26, member 9; targeted mutation 1, Manoocher Soleimani
• MGI ID: MGI:3822918
• Gene: Slc26a9 Location: Chr1:131671760-131699242 bp, + strand Genetic Position: Chr1, 57.18 cM
• Alliance: Slc26a9^tm1Sole page

Gastric mucosa abnormalities in Slc26a9^tm1Sole/Slc26a9^tm1Sole mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142516
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 5 were replaced with a neo cassette. The absence of transcript expression was confirmed by northern blot analysis on stomach and lung extracts. (J:142516)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc26a9 Mutation: 76 strains or lines available

References

• Original: J:142516 Xu J, et al., Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17955-60
• All: 6 reference(s)