Fgfr3^tm1Schl
Targeted Allele Detail

Summary

• Symbol: Fgfr3^tm1Schl
• Name: fibroblast growth factor receptor 3; targeted mutation 1, Joseph Schlessinger
• MGI ID: MGI:3823022
• Synonyms: Fgfr3b^-
• Gene: Fgfr3 Location: Chr5:33879068-33894412 bp, + strand Genetic Position: Chr5, 17.83 cM, cytoband B
• Alliance: Fgfr3^tm1Schl page

Morphological analysis of Fgfr3^tm1Schl/Fgfr3^tm1Schl and Fgfr3^tm2Schl/Fgfr3^tm2Schl mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142946
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neomycin expression cassette was inserted into intron 9 and a stop codon was inserted in exon 8. This results in an incomplete and misfolded D3 segment in the epithelial or b isoform. Chimeric mice were mated to Tg(ACTB-cre)2Mrt mice to excise the floxed neo cassette. (J:142946)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr3 Mutation: 54 strains or lines available

References

• Original: J:142946 Eswarakumar VP, et al., Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3937-42
• All: 1 reference(s)