Htr2c^tm1Knk
Targeted Allele Detail

Summary

• Symbol: Htr2c^tm1Knk
• Name: 5-hydroxytryptamine (serotonin) receptor 2C; targeted mutation 1, Kazuko Nishikura
• MGI ID: MGI:3823041
• Synonyms: 5-HT2CR-VGV
• Gene: Htr2c Location: ChrX:145745509-145980273 bp, + strand Genetic Position: ChrX, 68.46 cM, cytoband D-F4
• Alliance: Htr2c^tm1Knk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142503
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 5 was replaced with one in which 5 adenosines were converted to guanosines by nucleotide substitutions giving rise to I156V, N158G and I160V amino acid substitutions. A floxed neo cassette was inserted upstream of exon 5 for selection purposes. Mice only express the isoform carrying these substitutions. (J:142503)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Htr2c Mutation: 13 strains or lines available

References

• Original: J:142503 Kawahara Y, et al., Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass. J Neurosci. 2008 Nov 26;28(48):12834-44
• All: 4 reference(s)