Htr2c^tm2Knk
Targeted Allele Detail

Summary

• Symbol: Htr2c^tm2Knk
• Name: 5-hydroxytryptamine (serotonin) receptor 2C; targeted mutation 2, Kazuko Nishikura
• MGI ID: MGI:3823042
• Synonyms: 5-HT2CR-INI
• Gene: Htr2c Location: ChrX:145745509-145980273 bp, + strand Genetic Position: ChrX, 68.46 cM, cytoband D-F4
• Alliance: Htr2c^tm2Knk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142503
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Intragenic deletion
• Mutation details: The editing complimentary sequence in intron 5 was deleted to block RNA editing of adenosine to inosine at positions 156, 158 and 160. Mice only express the isoform carrying I156, N158, and I160 (INI). (J:142503)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Htr2c Mutation: 13 strains or lines available

References

• Original: J:142503 Kawahara Y, et al., Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass. J Neurosci. 2008 Nov 26;28(48):12834-44
• All: 2 reference(s)