Ift88^cbbs
Chemically induced Allele Detail

Summary

• Symbol: Ift88^cbbs
• Name: intraflagellar transport 88; cobblestone
• MGI ID: MGI:3823090
• Synonyms: cbs
• Gene: Ift88 Location: Chr14:57661519-57755393 bp, + strand Genetic Position: Chr14, 30.1 cM
• Alliance: Ift88^cbbs page

Mutation origin

• Strain of Origin: B6.129S4-Mapt^tm1(EGFP)Klt

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Not Specified
• Mutation details: The locus maps 0.5 cM distal to the marker D14Mit259. No mutations were identified in the coding region or 5' and 3' untranslated regions on the single candidate gene to account for the 70% to 80% reduction in transcript and protein expression confirmed by northern and western blot analysis of E12.5 brain extracts. Authors speculate that the ENU mutation must reside in an intronic or regulatory sequence. (J:142500)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ift88 Mutation: 48 strains or lines available

References

• Original: J:142500 Willaredt MA, et al., A crucial role for primary cilia in cortical morphogenesis. J Neurosci. 2008 Nov 26;28(48):12887-900
• All: 3 reference(s)