Tg(GATA6-cre)#Jbeb
Transgene Detail

Summary

• Symbol: Tg(GATA6-cre)#Jbeb
• Name: transgene insertion #, John B E Burch
• MGI ID: MGI:3823206
• Synonyms: cGATA6-cre, cGATA-6/Cre, Tg(GATA6-cre)Jbeb
• Transgene: Tg(GATA6-cre)#Jbeb Location: unknown
• Alliance: Tg(GATA6-cre)#Jbeb page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(GATA6-cre)#Jbeb expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  chicken	GATA6 (396390)

• Mutation details: A 2.3 kb chicken GATA6 gene fragment including the promoter drives the expression of cre in the developing atrioventricular conduction system. Two lines were generated and no distinction is made between the lines. (J:71908)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	GATA6 (chicken) Summary of all recombinase alleles driven by GATA6. Comparative matrix view of recombinase activities

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
cn1	Tbx3^tm3.1Moon/Tbx3^tm3.1Moon Tg(GATA6-cre)#Jbeb/0	involves: 129 * C57BL/6
cn2  Disease Model	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(GATA6-cre)#Jbeb/0	involves: 129S7/SvEvBrd * C57BL/6 * FVB

Phenotypes:

Affected Systems	cn1	cn2
show or hide all annotated terms
cardiovascular system	√	√
abnormal mitral valve cusp morphology		√
abnormal tricuspid valve morphology		√
Ebstein's malformation of tricuspid valve		√
abnormal tricuspid valve cusp morphology		√
decreased heart left ventricle muscle contractility		√
mitral valve regurgitation		√
abnormal impulse conducting system conduction		√
absent PR interval		√
atrioventricular block	√
muscle		√
decreased heart left ventricle muscle contractility		√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	cn2
Ebstein anomaly IDs Ebstein anomaly       DOID:14289 ICD10CM:Q22.5 ICD9CM:746.2 MESH:D004437 NCI:C84681 OMIM:224700 UMLS_CUI:C0013481 Close	√
Wolff-Parkinson-White syndrome IDs Wolff-Parkinson-White syndrome       DOID:384 DOID:10392 ICD10CM:I45.6 ICD9CM:426.7 MESH:D014927 NCI:C35132 OMIM:194200 UMLS_CUI:C0043202 UMLS_CUI:C0392470 Close	√

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:71908 Davis DL, et al., A GATA-6 gene heart-region-specific enhancer provides a novel means to mark and probe a discrete component of the mouse cardiac conduction system. Mech Dev. 2001 Oct;108(1-2):105-19
• All: 5 reference(s)