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Tg(GATA6-cre)#Jbeb
Transgene Detail
Summary
Symbol: Tg(GATA6-cre)#Jbeb
Name: transgene insertion #, John B E Burch
MGI ID: MGI:3823206
Synonyms: cGATA6-cre, cGATA-6/Cre, Tg(GATA6-cre)Jbeb
Transgene: Tg(GATA6-cre)#Jbeb  Location: unknown  
Alliance: Tg(GATA6-cre)#Jbeb page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(GATA6-cre)#Jbeb expression driven by 1 gene
 
Mutation detailsA 2.3 kb chicken GATA6 gene fragment including the promoter drives the expression of cre in the developing atrioventricular conduction system. Two lines were generated and no distinction is made between the lines. (J:71908)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: GATA6 (chicken)
Summary of all recombinase alleles driven by GATA6.
 

Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
involves: 129 * C57BL/6
 
cn2  Disease Model
involves: 129S7/SvEvBrd * C57BL/6 * FVB
 
Phenotypes:
Affected Systems
show or hide all annotated terms
   
cardiovascular system
abnormal mitral valve cusp morphology
abnormal tricuspid valve morphology
Ebstein's malformation of tricuspid valve
abnormal tricuspid valve cusp morphology
decreased heart left ventricle muscle contractility
mitral valve regurgitation
abnormal impulse conducting system conduction
absent PR interval
atrioventricular block
muscle
decreased heart left ventricle muscle contractility
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Key:
disease model   expected model not found
Models:
Human Diseases
cn2
IDs
IDs
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:71908 Davis DL, et al., A GATA-6 gene heart-region-specific enhancer provides a novel means to mark and probe a discrete component of the mouse cardiac conduction system. Mech Dev. 2001 Oct;108(1-2):105-19
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory

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