Ezh2^tm2.1Sho
Targeted Allele Detail

Summary

• Symbol: Ezh2^tm2.1Sho
• Name: enhancer of zeste 2 polycomb repressive complex 2 subunit; targeted mutation 2.1 Stuart Orkin
• MGI ID: MGI:3823218
• Synonyms: Ezh2^-
• Gene: Ezh2 Location: Chr6:47507073-47572275 bp, - strand Genetic Position: Chr6, 22.92 cM, cytoband B
• Alliance: Ezh2^tm2.1Sho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142193
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, Cre-mediated recombination was used to remove exons 14 and 15. The absence of protein expression was confirmed by western blot analysis on embryonic stem cells. (J:142193)

Disease models

Expression

In Mice Carrying this Mutation:	4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ezh2 Mutation: 72 strains or lines available

References

• Original: J:142193 Shen X, et al., EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell. 2008 Nov 21;32(4):491-502
• All: 4 reference(s)