Clec2d^tm1.1Mgil
Targeted Allele Detail

Summary

• Symbol: Clec2d^tm1.1Mgil
• Name: C-type lectin domain family 2, member d; targeted mutation 1.1, Matthew T Gillespie
• MGI ID: MGI:3826396
• Synonyms: Ocil^-
• Gene: Clec2d Location: Chr6:129157578-129163497 bp, + strand Genetic Position: Chr6, 63.16 cM, cytoband F3
• Alliance: Clec2d^tm1.1Mgil page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143122
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3 and a downstream floxed neo cassettes was inserted downstream of exon 3. Chimeric progeny were bred with a cre deleter strain to remove exon 3, leaving behind a single loxP site. Gene inactivation was confirmed by Southern blotting of cDNA derived from tail mRNA. Expression levels of Clec2g and Clec2i genes were unaffected in these mice. (J:143122)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Clec2d Mutation: 18 strains or lines available

References

• Original: J:143122 Kartsogiannis V, et al., Osteoclast inhibitory lectin, an immune cell product that is required for normal bone physiology in vivo. J Biol Chem. 2008 Nov 7;283(45):30850-60
• All: 6 reference(s)