Rhoh^tm1Brak
Targeted Allele Detail

Summary

• Symbol: Rhoh^tm1Brak
• Name: ras homolog family member H; targeted mutation 1, Cord Brakebusch
• MGI ID: MGI:3826431
• Synonyms: RhoH^-
• Gene: Rhoh Location: Chr5:66018556-66054043 bp, + strand Genetic Position: Chr5, 33.8 cM, cytoband D
• Alliance: Rhoh^tm1Brak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143161
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 0.9 kb fragment encoding the first 42 amino acids was replaced with a neomycin resistance cassette. This removes the translation start site and the switch 1 region. Northern blot analysis indicated that no normal protein was expressed. (J:143161)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rhoh Mutation: 13 strains or lines available

References

• Original: J:143161 Dorn T, et al., RhoH is important for positive thymocyte selection and T-cell receptor signaling. Blood. 2007 Mar 15;109(6):2346-55
• All: 5 reference(s)