Cyb5a^tm1Wolf
Targeted Allele Detail

Summary

• Symbol: Cyb5a^tm1Wolf
• Name: cytochrome b5 type A (microsomal); targeted mutation 1, C Roland Wolf
• MGI ID: MGI:3826663
• Synonyms: Cytb5^lox
• Gene: Cyb5a Location: Chr18:84869463-84897996 bp, + strand Genetic Position: Chr18, 57.53 cM
• Alliance: Cyb5a^tm1Wolf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143097
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 2 and an additional site was inserted downstream of exon 5. (J:143097)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyb5a Mutation: 20 strains or lines available

References

• Original: J:143097 Finn RD, et al., Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5. J Biol Chem. 2008 Nov 14;283(46):31385-93
• All: 2 reference(s)