Tm7sf2^tm1Riro
Targeted Allele Detail

Summary

• Symbol: Tm7sf2^tm1Riro
• Name: transmembrane 7 superfamily member 2; targeted mutation 1, Rita Roberti
• MGI ID: MGI:3826687
• Gene: Tm7sf2 Location: Chr19:6112851-6117880 bp, - strand Genetic Position: Chr19, 4.34 cM, cytoband A
• Alliance: Tm7sf2^tm1Riro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143116
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted into exon 5. The absence of protein expression was confirmed by western blot analysis on liver microsomes. (J:143116)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tm7sf2 Mutation: 30 strains or lines available

References

• Original: J:143116 Bennati AM, et al., Disruption of the gene encoding 3beta-hydroxysterol Delta-reductase (Tm7sf2) in mice does not impair cholesterol biosynthesis. FEBS J. 2008 Oct;275(20):5034-47
• All: 7 reference(s)