Tg(Tcra,Tcrb)9Rest
Transgene Detail

Summary

• Symbol: Tg(Tcra,Tcrb)9Rest
• Name: transgene insertion 9, Nicholas P Restifo
• MGI ID: MGI:3826818
• Synonyms: TRP-1 TCR
• Transgene: Tg(Tcra,Tcrb)9Rest Location: unknown Genetic Position: ChrY, Syntenic
• Alliance: Tg(Tcra,Tcrb)9Rest page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tcra,Tcrb)9Rest expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: The TRP-1 TCR was generated from immunized Tyrp1B-w mice. Clone 7A6 expressed Valpha3.2Vbeta14 TCR chains. These TCR sequences were cloned into separate vectors and co-injected into microinjected into C57BL/6 fertilized eggs. Founder line 9 was subsequently established and the transgene insertion site was found on the Y chromosome. (J:138466)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:138466 Muranski P, et al., Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood. 2008 Jul 15;112(2):362-73
• All: 28 reference(s)