Dnm3os^tm1Tkk
Targeted Allele Detail

Summary

• Symbol: Dnm3os^tm1Tkk
• Name: dynamin 3, opposite strand; targeted mutation 1, Takashi Nakaoka
• MGI ID: MGI:3826836
• Synonyms: Dnm3os^lacZ
• Gene: Dnm3os Location: Chr1:162045192-162053119 bp, + strand Genetic Position: Chr1, 70.06 cM
• Alliance: Dnm3os^tm1Tkk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143209
• Parent Cell Line: ATOM1 (ES Cell)
• Strain of Origin: (C57BL/6 x 129)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ gene with a nuclear localization signal and 5' lox71 site followed by a neo cassette flanked by lox2272 sites replaces the 5' region of the single exon. The absence of transcript expression was confirmed by northern blot analysis on E10.5 embryos extracts. Transcript expression of Mirn214 is undetectable and that of Mirn199a-2 is downregulated. (J:143209)

Expression

In Mice Carrying this Mutation:	60 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnm3os Mutation: 1 strain or line available

References

• Original: J:143209 Watanabe T, et al., Dnm3os, a non-coding RNA, is required for normal growth and skeletal development in mice. Dev Dyn. 2008 Dec;237(12):3738-48
• All: 2 reference(s)