Arg1^tm1.1Pmu
Targeted Allele Detail

Summary

• Symbol: Arg1^tm1.1Pmu
• Name: arginase, liver; targeted mutation 1.1, Peter J Murray
• MGI ID: MGI:3826848
• Synonyms: Arg1^delta
• Gene: Arg1 Location: Chr10:24791105-24803368 bp, - strand Genetic Position: Chr10, 12.26 cM
• Alliance: Arg1^tm1.1Pmu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143229
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Mice carrying the floxed allele Arg1^tm1Pmu were crossed with a transgenic cre recombinase mouse strain to remove exons 7 and 8 from germline cells. Gene inactivation was confirmed by genomic PCR. This is a null allele. (J:143229)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arg1 Mutation: 28 strains or lines available

References

• Original: J:143229 El Kasmi KC, et al., Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol. 2008 Dec;9(12):1399-406
• All: 4 reference(s)