Dusp6^tm1Jmol
Targeted Allele Detail

Summary

• Symbol: Dusp6^tm1Jmol
• Name: dual specificity phosphatase 6; targeted mutation 1, Jeffery D Molkentin
• MGI ID: MGI:3827011
• Gene: Dusp6 Location: Chr10:99099093-99103351 bp, + strand Genetic Position: Chr10, 51.13 cM, cytoband C3
• Alliance: Dusp6^tm1Jmol page

Increased satellite cell numbers in Dusp6^tm1Jmol/Dusp6^tm1Jmol regenerating muscle following injury

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142966
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All 3 exons were replaced with a neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein in the lung, spleen, thymus, and heart of homozygous mice. (J:142966)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dusp6 Mutation: 29 strains or lines available

References

• Original: J:142966 Maillet M, et al., DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility. J Biol Chem. 2008 Nov 7;283(45):31246-55
• All: 16 reference(s)