Dock5^{Gt(AN0268)Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: Dock5^{Gt(AN0268)Wtsi}
• Name: dedicator of cytokinesis 5; gene trap AN0268, Wellcome Trust Sanger Institute
• MGI ID: MGI:3828069
• Synonyms: D5^-
• Gene: Dock5 Location: Chr14:67989584-68170891 bp, - strand Genetic Position: Chr14, 34.66 cM
• Alliance: Dock5^{Gt(AN0268)Wtsi} page

Mutation origin

• Mutant Cell Line: AN0268
• Germline Transmission: Earliest citation of germline transmission: J:143342
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Sanger Inst. Gene Trap Res.

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0lxr
• Mutation details: The gene trap vector pGTOlxr, which contains a beta-geo cassette, was inserted into intron 29. The absence of protein expression was confirmed by western blot analysis. (J:143342)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  AN0268	CW989553 ; (MGI Seq Detail)	5' RACE	Chr14:68019442-68024331 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  99 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:

17 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dock5 Mutation: 158 strains or lines available

References

• Original: J:143342 Laurin M, et al., The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15446-51
• All: 8 reference(s)