Gstt1^tm1Kfuj
Targeted Allele Detail

Summary

• Symbol: Gstt1^tm1Kfuj
• Name: glutathione S-transferase, theta 1; targeted mutation 1, Kazunori Fujimoto
• MGI ID: MGI:3828088
• Gene: Gstt1 Location: Chr10:75619647-75634418 bp, - strand Genetic Position: Chr10, 38.58 cM, cytoband B5-C1
• Alliance: Gstt1^tm1Kfuj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143552
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neomycin resistance cassette. Mutant ES cell clone 9D5 was used to generate chimeric mice. No mRNA expression coulld be detected in the livers of homozygotes by RT-PCR. (J:143552)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gstt1 Mutation: 16 strains or lines available

References

• Original: J:143552 Fujimoto K, et al., Generation and functional characterization of mice with a disrupted glutathione S-transferase, theta 1 gene. Drug Metab Dispos. 2007 Dec;35(12):2196-202
• All: 1 reference(s)