Npas4^tm1Meg
Targeted Allele Detail

Summary

• Symbol: Npas4^tm1Meg
• Name: neuronal PAS domain protein 4; targeted mutation 1, Michael E Greenberg
• MGI ID: MGI:3828099
• Gene: Npas4 Location: Chr19:5034383-5040344 bp, - strand Genetic Position: Chr19, 4.2 cM
• Alliance: Npas4^tm1Meg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143367
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The genomic sequence spanning part of exon 1 through exon 7 was replaced with a GFP gene and a floxed neo cassette. The neo cassette was removed by cre-mediated recombination. Absence of protein expression was confirmed by western blot analysis on KCl stimulated cortical neuron extracts. (J:143367)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npas4 Mutation: 27 strains or lines available

References

• Original: J:143367 Lin Y, et al., Activity-dependent regulation of inhibitory synapse development by Npas4. Nature. 2008 Oct 30;455(7217):1198-204
• All: 15 reference(s)