Tgq11^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Tgq11^DBA/2J
• Name: triglyceride QTL 11; DBA/2J
• MGI ID: MGI:3828109
• QTL: Tgq11 Location: Chr2:8324559-8324559 bp Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased plasma triglyceride concentrations after 8 weeks of high fat diet compared to DBA/1J. (J:142770)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:142770

Linkage analysis was performed using a backcross derived from closely related inbred strains DBA/1J and DBA/2J. The genetic composition of these 2 inbred strains differs by just 5.6% at the SNP level. A total of 294 mice from (DBA/1J x DBA/2J)F1 x DBA/1Jand (DBA/1J x DBA/2J)F1 x DBA/2J populations were screened for 6,949 polymorphic SNP markers. Backcross mice were placed on a high-fat diet at 8 weeks of age and phenotyped for plasma triglyceride and HDL concentrations at 8, 11 and 16 weeks of age. Parental strain DBA/2J displays significantly increased plasma triglyceride concentrations on a CHOW diet compared to parental strain DBA/1J. Male DBA/2J animals display significantly increased plasma triglyceride and HDL concentrations after an 8 week high fat diet compared to DBA/1J males.

On mouse Chromosome 2, linkage to plasma triglyceride concentration after 3 weeks on a high fat diet mapped to 3 cM near rs13476339 (8.24 Mb) with LOD=4.5 and is named Tgq10 (triglyceride QTL 10). Linkage to triglyceridelevels after 8 weeks of high fat diet mapped to 27 cM (also near rs13476339) with LOD=5.1 and is named Tgq11 (triglyceride QTL 11). DBA/2J-derived alleles at Tgq10 and Tgq11 confer increased triglyceride concentrations. The confidence interval for Tgq10 and Tgq11 both span the same region between 0 cM and 30 cM.

Suggestive linkage to triglycerides on a CHOW diet mapped to 75 cM (LOD=2.9) and is named Tgq12 (triglyceride QTL 12). This QTL has also been detected in previous crosses. [Table 3].

References

• Original: J:142770 Stylianou IM, et al., Differences in DBA/1J and DBA/2J reveal lipid QTL genes. J Lipid Res. 2008 Nov;49(11):2402-13
• All: 1 reference(s)